Enables RNA binding activity. Predicted to be involved in maturation of SSU-rRNA. Predicted to be located in perinuclear region of cytoplasm. Predicted to be part of 90S preribosome. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SRFBP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SRFBP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SRFBP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:120,621,047–120,622,069 | 1340.5 kb | Distal (>10kb) Multiome HiCAR | 150 | |
| chr5:120,702,537–120,703,600 | 1258.7 kb | Distal (>10kb) Multiome HiCAR | 138 | |
| chr5:120,706,369–120,707,487 | 1254.9 kb | Distal (>10kb) Multiome HiCAR | 230 | |
| chr5:121,691,367–121,692,102 | 270.3 kb | Distal (>10kb) Multiome | 192 | |
| chr5:121,961,557–121,962,409 | 72 bp | At TSS Multiome | 978 | |
| chr5:122,076,611–122,078,738 | 116.3 kb | Distal (>10kb) Multiome | 761 |
Genomic view of the SRFBP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.