Predicted to enable mRNA binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SRBD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SRBD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SRBD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:45,610,482–45,611,481 | 3 bp | At TSS Multiome | 821 | |
| chr2:45,616,746–45,616,935 | 5.5 kb | Proximal (<10kb) | 26 | |
| chr2:45,620,911–45,621,478 | 10.0 kb | Proximal (<10kb) Multiome | 10 | |
| chr2:45,643,037–45,644,148 | 32.5 kb | Distal (>10kb) Multiome | 559 | |
| chr2:45,649,929–45,651,840 | 39.9 kb | Distal (>10kb) Multiome | 922 |
Genomic view of the SRBD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.