Enables ubiquitin-like ligase-substrate adaptor activity. Involved in several processes, including positive regulation of protein polyubiquitination; protein ubiquitination; and ubiquitin-dependent protein catabolic process. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SPSB4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SPSB4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SPSB4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:140,941,304–140,943,041 | 108.5 kb | Distal (>10kb) Multiome | 1087 | |
| chr3:141,050,639–141,052,361 | 27 bp | At TSS Multiome | 469 | |
| chr3:141,052,555–141,053,072 | 1.2 kb | Proximal (<10kb) | 162 | |
| chr3:141,070,840–141,071,438 | 19.8 kb | Distal (>10kb) Multiome | 164 | |
| chr3:141,074,501–141,074,972 | 23.3 kb | Distal (>10kb) Multiome | 69 | |
| chr3:141,231,050–141,232,888 | 180.4 kb | Distal (>10kb) Multiome | 693 | |
| chr3:141,311,338–141,312,269 | 260.5 kb | Distal (>10kb) Multiome | 905 |
Genomic view of the SPSB4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.