Involved in positive regulation of SREBP signaling pathway. Located in Golgi membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SPRING1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SPRING1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SPRING1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:115,207,704–115,208,364 | 1530.1 kb | Distal (>10kb) Multiome HiCAR | 25 | |
| chr12:116,506,096–116,506,922 | 231.6 kb | Distal (>10kb) Multiome | 123 | |
| chr12:116,508,269–116,509,006 | 229.6 kb | Distal (>10kb) Multiome | 291 | |
| chr12:116,533,039–116,534,478 | 204.6 kb | Distal (>10kb) Multiome | 430 | |
| chr12:116,694,557–116,695,015 | 43.3 kb | Distal (>10kb) Multiome | 37 | |
| chr12:116,697,179–116,697,642 | 40.7 kb | Distal (>10kb) Multiome | 129 | |
| chr12:116,736,162–116,736,517 | 1.6 kb | Proximal (<10kb) | 213 | |
| chr12:116,737,743–116,738,634 | 104 bp | At TSS Multiome | 852 | |
| chr12:116,818,976–116,819,922 | 81.5 kb | Distal (>10kb) Multiome | 760 | |
| chr12:116,876,126–116,876,628 | 138.4 kb | Distal (>10kb) Multiome | 82 | |
| chr12:116,880,733–116,881,665 | 143.1 kb | Distal (>10kb) Multiome HiCAR | 509 | |
| chr12:116,910,746–116,911,448 | 173.0 kb | Distal (>10kb) Multiome | 902 |
Genomic view of the SPRING1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.