This gene encodes a protein that belongs to the TFIIS family of transcription factors. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Transcription factors with Perturb-seq knockdown data for SPOCD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SPOCD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SPOCD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:31,548,778–31,549,765 | 266.8 kb | Distal (>10kb) Multiome | 641 | |
| chr1:31,617,603–31,618,426 | 197.8 kb | Distal (>10kb) Multiome | 345 | |
| chr1:31,644,333–31,645,606 | 171.0 kb | Distal (>10kb) Multiome | 926 | |
| chr1:31,647,107–31,647,947 | 168.4 kb | Distal (>10kb) Multiome | 49 | |
| chr1:31,714,302–31,716,109 | 100.7 kb | Distal (>10kb) Multiome | 759 | |
| chr1:31,760,521–31,761,442 | 55.1 kb | Distal (>10kb) Multiome | 317 | |
| chr1:31,762,648–31,763,343 | 53.2 kb | Distal (>10kb) Multiome | 402 | |
| chr1:31,764,083–31,764,672 | 51.6 kb | Distal (>10kb) Multiome | 263 | |
| chr1:31,769,677–31,770,397 | 45.8 kb | Distal (>10kb) Multiome | 185 | |
| chr1:31,776,109–31,776,832 | 39.5 kb | Distal (>10kb) Multiome | 86 | |
| chr1:31,788,126–31,789,694 | 27.3 kb | Distal (>10kb) Multiome | 713 | |
| chr1:31,815,736–31,816,251 | 35 bp | At TSS Multiome | 666 | |
| chr1:31,937,587–31,938,944 | 122.5 kb | Distal (>10kb) Multiome HiCAR | 1111 | |
| chr1:31,943,994–31,945,090 | 128.6 kb | Distal (>10kb) Multiome HiCAR | 826 | |
| chr1:31,954,721–31,955,545 | 139.1 kb | Distal (>10kb) Multiome HiCAR | 628 | |
| chr1:32,013,168–32,015,085 | 197.7 kb | Distal (>10kb) Multiome | 988 | |
| chr1:32,072,319–32,073,738 | 257.2 kb | Distal (>10kb) Multiome | 909 | |
| chr1:32,107,881–32,108,706 | 292.1 kb | Distal (>10kb) Multiome | 779 |
Genomic view of the SPOCD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.