Involved in DNA damage response and negative regulation of DNA-templated transcription. Is active in nucleus and site of DNA damage. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SPINDOC. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SPINDOC upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SPINDOC, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:63,613,506–63,614,656 | 199.1 kb | Distal (>10kb) Multiome | 502 | |
| chr11:63,670,776–63,672,118 | 141.8 kb | Distal (>10kb) Multiome | 715 | |
| chr11:63,680,920–63,682,270 | 132.0 kb | Distal (>10kb) Multiome | 869 | |
| chr11:63,761,764–63,765,204 | 49.3 kb | Distal (>10kb) Multiome | 463 | |
| chr11:63,767,471–63,769,982 | 45.9 kb | Distal (>10kb) Multiome | 627 | |
| chr11:63,813,022–63,814,238 | 5 bp | At TSS Multiome | 704 | |
| chr11:63,838,214–63,839,799 | 25.5 kb | Distal (>10kb) Multiome | 687 | |
| chr11:63,888,171–63,888,861 | 75.1 kb | Distal (>10kb) Multiome | 565 | |
| chr11:63,909,610–63,910,221 | 96.5 kb | Distal (>10kb) Multiome | 113 | |
| chr11:63,916,069–63,921,372 | 106.0 kb | Distal (>10kb) Multiome | 929 | |
| chr11:63,938,087–63,939,846 | 125.4 kb | Distal (>10kb) Multiome | 852 | |
| chr11:63,974,156–63,975,123 | 161.1 kb | Distal (>10kb) Multiome | 918 | |
| chr11:63,986,198–63,987,213 | 173.1 kb | Distal (>10kb) Multiome | 895 | |
| chr11:63,998,533–64,001,109 | 186.0 kb | Distal (>10kb) Multiome | 414 | |
| chr11:64,028,126–64,028,898 | 215.2 kb | Distal (>10kb) Multiome | 168 |
Genomic view of the SPINDOC locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.