Involved in metaphase chromosome alignment; mitotic spindle assembly; and regulation of centriole replication. Located in intracellular membrane-bounded organelle; microtubule cytoskeleton; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for SPICE1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SPICE1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SPICE1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:113,240,837–113,244,224 | 273.4 kb | Distal (>10kb) Multiome | 545 | |
| chr3:113,441,051–113,442,064 | 73.6 kb | Distal (>10kb) Multiome | 198 | |
| chr3:113,514,383–113,515,648 | 11 bp | At TSS Multiome | 705 | |
| chr3:113,532,401–113,533,734 | 17.9 kb | Distal (>10kb) Multiome | 388 | |
| chr3:113,695,756–113,697,740 | 181.6 kb | Distal (>10kb) Multiome | 796 | |
| chr3:113,744,989–113,747,921 | 230.1 kb | Distal (>10kb) Multiome | 1061 |
Genomic view of the SPICE1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.