Enables protein-macromolecule adaptor activity. Involved in sperm-egg recognition. Is active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SPACA6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SPACA6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SPACA6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:51,393,803–51,394,830 | 309.6 kb | Distal (>10kb) Multiome | 725 | |
| chr19:51,570,986–51,571,539 | 132.8 kb | Distal (>10kb) Multiome | 515 | |
| chr19:51,593,934–51,594,889 | 109.5 kb | Distal (>10kb) Multiome | 581 | |
| chr19:51,687,813–51,691,477 | 14.8 kb | Distal (>10kb) Multiome | 820 | |
| chr19:51,702,162–51,704,690 | 203 bp | At TSS Multiome | 758 | |
| chr19:51,712,573–51,712,977 | 8.6 kb | Proximal (<10kb) | 104 | |
| chr19:51,904,568–51,905,180 | 201.0 kb | Distal (>10kb) Multiome | 662 | |
| chr19:51,926,700–51,927,523 | 223.1 kb | Distal (>10kb) Multiome | 675 | |
| chr19:51,960,144–51,961,162 | 256.8 kb | Distal (>10kb) Multiome | 242 |
Genomic view of the SPACA6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.