Arg and c-Abl represent the mammalian members of the Abelson family of non-receptor protein-tyrosine kinases. They interact with the Arg/Abl binding proteins via the SH3 domains present in the carboxy end of the latter group of proteins. This gene encodes the sorbin and SH3 domain containing 2 protein. It has three C-terminal SH3 domains and an N-terminal sorbin homology (SoHo) domain that interacts with lipid raft proteins. The subcellular localization of this protein in epithelial and cardiac muscle cells suggests that it functions as an adapter protein to assemble signaling complexes in stress fibers, and that it is a potential link between Abl family kinases and the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for SORBS2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SORBS2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SORBS2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:185,534,729–185,535,832 | 276.8 kb | Distal (>10kb) Multiome | 535 | |
| chr4:185,805,313–185,806,262 | 6.0 kb | Proximal (<10kb) | 126 | |
| chr4:185,810,930–185,811,130 | 1.1 kb | Proximal (<10kb) | 294 | |
| chr4:185,811,761–185,812,348 | at TSS | At TSS | 350 | |
| chr4:185,838,997–185,839,673 | 27.2 kb | Distal (>10kb) Multiome | 329 | |
| chr4:186,081,208–186,081,652 | 269.2 kb | Distal (>10kb) Multiome | 58 | |
| chr4:186,104,365–186,105,711 | 292.7 kb | Distal (>10kb) Multiome | 349 |
Genomic view of the SORBS2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.