Predicted to enable phosphatidylinositol binding activity and type I transforming growth factor beta receptor binding activity. Involved in negative regulation of transforming growth factor beta receptor signaling pathway and receptor catabolic process. Located in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for SNX25. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SNX25 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SNX25, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:184,983,798–184,984,312 | 220.1 kb | Distal (>10kb) Multiome | 307 | |
| chr4:185,004,689–185,005,528 | 199.0 kb | Distal (>10kb) Multiome | 348 | |
| chr4:185,018,062–185,018,650 | 185.7 kb | Distal (>10kb) Multiome | 181 | |
| chr4:185,115,806–185,116,379 | 88.1 kb | Distal (>10kb) Multiome | 365 | |
| chr4:185,127,221–185,129,177 | 76.6 kb | Distal (>10kb) Multiome | 406 | |
| chr4:185,142,664–185,143,838 | 61.0 kb | Distal (>10kb) Multiome | 886 | |
| chr4:185,203,468–185,204,322 | 227 bp | At TSS Multiome | 710 | |
| chr4:185,209,029–185,211,342 | 5.3 kb | Proximal (<10kb) Multiome | 699 | |
| chr4:185,212,760–185,213,271 | 8.5 kb | Proximal (<10kb) | 36 | |
| chr4:185,235,783–185,236,350 | 31.8 kb | Distal (>10kb) Multiome | 289 | |
| chr4:185,318,614–185,319,089 | 114.7 kb | Distal (>10kb) Multiome | 382 | |
| chr4:185,395,863–185,397,395 | 192.4 kb | Distal (>10kb) Multiome | 1140 | |
| chr4:185,425,371–185,426,547 | 221.8 kb | Distal (>10kb) Multiome | 873 | |
| chr4:185,470,476–185,472,157 | 267.1 kb | Distal (>10kb) Multiome | 628 |
Genomic view of the SNX25 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.