Islet antigen-2 (IA-2) is an autoantigen in type 1 diabetes and plays a role in insulin secretion. IA-2 is found in dense-core secretory vesicles and interacts with the product of this gene, a sorting nexin. In mouse pancreatic beta-cells, the encoded protein influenced insulin secretion by stabilizing the number of dense-core secretory vesicles. [provided by RefSeq, Dec 2016]
Transcription factors with Perturb-seq knockdown data for SNX19. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SNX19 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SNX19, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:130,423,717–130,424,508 | 492.5 kb | Distal (>10kb) Multiome HiCAR | 77 | |
| chr11:130,448,217–130,449,643 | 467.9 kb | Distal (>10kb) Multiome HiCAR | 449 | |
| chr11:130,449,732–130,450,570 | 466.3 kb | Distal (>10kb) Multiome HiCAR | 212 | |
| chr11:130,827,628–130,828,316 | 88.5 kb | Distal (>10kb) Multiome | 244 | |
| chr11:130,861,810–130,862,310 | 54.3 kb | Distal (>10kb) Multiome | 489 | |
| chr11:130,876,155–130,876,673 | 40.1 kb | Distal (>10kb) Multiome | 26 | |
| chr11:130,916,036–130,916,933 | 67 bp | At TSS Multiome | 639 | |
| chr11:130,923,395–130,923,571 | 6.9 kb | Proximal (<10kb) | 95 |
Genomic view of the SNX19 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.