Dystrophin is a large, rod-like cytoskeletal protein found at the inner surface of muscle fibers. Dystrophin is missing in Duchenne Muscular Dystrophy patients and is present in reduced amounts in Becker Muscular Dystrophy patients. The protein encoded by this gene is a peripheral membrane protein found associated with dystrophin and dystrophin-related proteins. This gene is a member of the syntrophin gene family, which contains at least two other structurally-related genes. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for SNTB1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SNTB1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SNTB1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:119,415,758–119,417,536 | 1395.2 kb | Distal (>10kb) Multiome HiCAR | 611 | |
| chr8:120,805,954–120,806,361 | 5.7 kb | Proximal (<10kb) | 23 | |
| chr8:120,808,507–120,809,333 | 2.7 kb | Proximal (<10kb) | 411 | |
| chr8:120,809,567–120,812,875 | 195 bp | At TSS Multiome | 1036 | |
| chr8:120,904,097–120,905,145 | 92.5 kb | Distal (>10kb) Multiome | 74 |
Genomic view of the SNTB1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.