Syntrophins are cytoplasmic peripheral membrane scaffold proteins that are components of the dystrophin-associated protein complex. This gene is a member of the syntrophin gene family and encodes the most common syntrophin isoform found in cardiac tissues. The N-terminal PDZ domain of this syntrophin protein interacts with the C-terminus of the pore-forming alpha subunit (SCN5A) of the cardiac sodium channel Nav1.5. This protein also associates cardiac sodium channels with the nitric oxide synthase-PMCA4b (plasma membrane Ca-ATPase subtype 4b) complex in cardiomyocytes. This gene is a susceptibility locus for Long-QT syndrome (LQT) - an inherited disorder associated with sudden cardiac death from arrhythmia - and sudden infant death syndrome (SIDS). This protein also associates with dystrophin and dystrophin-related proteins at the neuromuscular junction and alters intracellular calcium ion levels in muscle tissue. [provided by RefSeq, Jan 2013]
Transcription factors with Perturb-seq knockdown data for SNTA1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SNTA1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SNTA1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:33,443,149–33,444,777 | 113 bp | At TSS Multiome | 726 | |
| chr20:33,444,953–33,445,172 | 1.2 kb | Proximal (<10kb) | 171 | |
| chr20:33,475,400–33,476,091 | 32.0 kb | Distal (>10kb) Multiome | 98 | |
| chr20:33,477,323–33,477,813 | 33.8 kb | Distal (>10kb) Multiome | 124 | |
| chr20:33,489,654–33,490,762 | 46.2 kb | Distal (>10kb) Multiome | 1000 | |
| chr20:33,663,243–33,664,235 | 220.0 kb | Distal (>10kb) Multiome HiCAR | 895 | |
| chr20:33,666,358–33,668,405 | 223.1 kb | Distal (>10kb) Multiome HiCAR | 603 | |
| chr20:33,673,732–33,675,136 | 230.7 kb | Distal (>10kb) Multiome | 826 | |
| chr20:33,685,755–33,686,963 | 242.8 kb | Distal (>10kb) Multiome | 830 | |
| chr20:33,720,042–33,720,684 | 276.6 kb | Distal (>10kb) Multiome | 584 | |
| chr20:33,731,496–33,732,906 | 288.4 kb | Distal (>10kb) Multiome | 1049 |
Genomic view of the SNTA1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.