The protein encoded by this gene is one of several nuclear proteins that are found in common among U1, U2, U4/U6, and U5 small ribonucleoprotein particles (snRNPs). These snRNPs are involved in pre-mRNA splicing, and the encoded protein may also play a role in pre-mRNA splicing or snRNP structure. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding different isoforms (B and B') have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for SNRPB. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SNRPB upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SNRPB, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:2,207,018–2,207,984 | 263.3 kb | Distal (>10kb) Multiome | 658 | |
| chr20:2,351,893–2,352,388 | 118.7 kb | Distal (>10kb) Multiome | 361 | |
| chr20:2,470,152–2,471,296 | 67 bp | At TSS Multiome | 1126 | |
| chr20:2,508,648–2,509,663 | 38.3 kb | Distal (>10kb) Multiome | 854 | |
| chr20:2,524,432–2,525,455 | 53.9 kb | Distal (>10kb) Multiome | 724 | |
| chr20:2,536,033–2,536,583 | 65.5 kb | Distal (>10kb) Multiome | 42 | |
| chr20:2,651,802–2,653,286 | 181.8 kb | Distal (>10kb) Multiome | 1060 | |
| chr20:2,663,925–2,664,409 | 193.5 kb | Distal (>10kb) Multiome | 908 | |
| chr20:2,692,159–2,694,013 | 221.8 kb | Distal (>10kb) Multiome | 584 | |
| chr20:2,752,636–2,753,047 | 282.0 kb | Distal (>10kb) Multiome | 395 |
Genomic view of the SNRPB locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.