Predicted to be involved in RNA processing. Predicted to be located in nucleolus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SNHG8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SNHG8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SNHG8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:118,032,782–118,034,513 | 245.1 kb | Distal (>10kb) Multiome | 503 | |
| chr4:118,174,834–118,176,016 | 103.1 kb | Distal (>10kb) Multiome | 184 | |
| chr4:118,265,324–118,266,279 | 13.0 kb | Distal (>10kb) Multiome | 210 | |
| chr4:118,270,553–118,270,722 | 8.0 kb | Proximal (<10kb) | 46 | |
| chr4:118,278,030–118,279,632 | 101 bp | At TSS Multiome | 1058 | |
| chr4:118,280,557–118,281,584 | 1.8 kb | Proximal (<10kb) | 320 | |
| chr4:118,281,630–118,283,535 | 2.9 kb | Proximal (<10kb) | 327 | |
| chr4:118,284,060–118,284,796 | 5.3 kb | Proximal (<10kb) | 111 | |
| chr4:118,351,851–118,353,862 | 74.2 kb | Distal (>10kb) Multiome | 619 |
Genomic view of the SNHG8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.