Predicted to enable RNA polymerase III type 3 promoter sequence-specific DNA binding activity and bent DNA binding activity. Predicted to contribute to RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and core promoter sequence-specific DNA binding activity. Predicted to be involved in snRNA transcription by RNA polymerase II and snRNA transcription by RNA polymerase III. Located in nuclear body and nucleolus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SNAPC3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SNAPC3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SNAPC3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:15,137,894–15,138,779 | 284.4 kb | Distal (>10kb) Multiome | 126 | |
| chr9:15,249,131–15,250,215 | 173.3 kb | Distal (>10kb) Multiome HiCAR | 244 | |
| chr9:15,306,092–15,307,952 | 115.6 kb | Distal (>10kb) Multiome | 885 | |
| chr9:15,354,632–15,356,131 | 67.9 kb | Distal (>10kb) Multiome | 170 | |
| chr9:15,416,800–15,417,192 | 5.7 kb | Proximal (<10kb) | 149 | |
| chr9:15,417,678–15,417,995 | 4.9 kb | Proximal (<10kb) | 27 | |
| chr9:15,422,127–15,423,372 | 140 bp | At TSS Multiome | 914 | |
| chr9:15,423,473–15,423,601 | 605 bp | At TSS | 80 | |
| chr9:15,510,031–15,511,595 | 88.2 kb | Distal (>10kb) Multiome | 913 | |
| chr9:15,512,558–15,513,923 | 90.5 kb | Distal (>10kb) Multiome | 289 | |
| chr9:15,529,900–15,530,578 | 107.4 kb | Distal (>10kb) Multiome | 210 | |
| chr9:15,551,866–15,553,797 | 130.2 kb | Distal (>10kb) Multiome | 898 |
Genomic view of the SNAPC3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.