This gene encodes a histone methyltransferase which functions in RNA polymerase II complexes by an interaction with a specific RNA helicase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Transcription factors with Perturb-seq knockdown data for SMYD3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SMYD3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SMYD3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:246,416,783–246,419,459 | 89.8 kb | Distal (>10kb) Multiome | 407 | |
| chr1:246,506,470–246,507,681 | 11 bp | At TSS Multiome | 631 | |
| chr1:246,565,796–246,567,114 | 59.2 kb | Distal (>10kb) Multiome | 926 | |
| chr1:246,723,808–246,725,073 | 217.0 kb | Distal (>10kb) Multiome | 777 | |
| chr1:246,753,796–246,754,434 | 246.8 kb | Distal (>10kb) Multiome | 194 |
Genomic view of the SMYD3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.