This gene encodes a ubiquitin ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. This protein plays a key roll in the regulation of cell motility, cell signalling, and cell polarity. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Dec 2010]
Transcription factors with Perturb-seq knockdown data for SMURF1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SMURF1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SMURF1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:98,878,144–98,879,418 | 265.5 kb | Distal (>10kb) Multiome | 817 | |
| chr7:99,142,006–99,144,629 | 1.7 kb | Proximal (<10kb) Multiome | 865 | |
| chr7:99,325,304–99,326,401 | 181.8 kb | Distal (>10kb) Multiome | 858 | |
| chr7:99,373,955–99,375,619 | 231.4 kb | Distal (>10kb) Multiome | 759 | |
| chr7:99,392,361–99,394,025 | 249.1 kb | Distal (>10kb) Multiome | 486 | |
| chr7:99,407,975–99,409,432 | 264.7 kb | Distal (>10kb) Multiome | 975 | |
| chr7:99,438,371–99,439,668 | 295.0 kb | Distal (>10kb) Multiome | 881 |
Genomic view of the SMURF1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.