This gene encodes a structural protein that is found exclusively in contractile smooth muscle cells. It associates with stress fibers and constitutes part of the cytoskeleton. This gene is localized to chromosome 22q12.3, distal to the TUPLE1 locus and outside the DiGeorge syndrome deletion. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2011]
Transcription factors with Perturb-seq knockdown data for SMTN. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SMTN upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SMTN, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:30,802,592–30,803,363 | 278.4 kb | Distal (>10kb) Multiome | 898 | |
| chr22:30,968,406–30,969,906 | 112.2 kb | Distal (>10kb) Multiome | 897 | |
| chr22:31,080,687–31,081,783 | 124 bp | At TSS Multiome | 636 | |
| chr22:31,084,596–31,085,743 | 3.8 kb | Proximal (<10kb) Multiome | 448 | |
| chr22:31,098,574–31,099,237 | 17.6 kb | Distal (>10kb) Multiome | 150 | |
| chr22:31,104,824–31,105,447 | 23.8 kb | Distal (>10kb) Multiome | 187 | |
| chr22:31,107,269–31,107,915 | 26.4 kb | Distal (>10kb) Multiome | 627 | |
| chr22:31,127,262–31,127,766 | 46.2 kb | Distal (>10kb) Multiome | 74 | |
| chr22:31,140,179–31,140,721 | 59.2 kb | Distal (>10kb) Multiome | 244 | |
| chr22:31,160,052–31,160,698 | 78.9 kb | Distal (>10kb) Multiome | 709 | |
| chr22:31,211,835–31,212,727 | 130.9 kb | Distal (>10kb) Multiome | 769 | |
| chr22:31,290,525–31,291,372 | 209.5 kb | Distal (>10kb) Multiome | 818 | |
| chr22:31,345,143–31,347,910 | 264.8 kb | Distal (>10kb) Multiome | 954 | |
| chr22:31,362,564–31,363,231 | 281.5 kb | Distal (>10kb) Multiome | 164 |
Genomic view of the SMTN locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.