This gene belongs to the 'structural maintenance of chromosomes' (SMC) gene family. Members of this gene family play a role in two changes in chromosome structure during mitotic segregation of chromosomes- chromosome condensation and sister chromatid cohesion. The protein encoded by this gene is likely a subunit of the 13S condensin complex, which is involved in chromosome condensation. A pseudogene related to this gene is located on chromosome 2. [provided by RefSeq, Jun 2016]
Transcription factors with Perturb-seq knockdown data for SMC4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SMC4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SMC4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:160,224,325–160,227,043 | 186.5 kb | Distal (>10kb) Multiome | 759 | |
| chr3:160,395,273–160,396,017 | 8.5 kb | Proximal (<10kb) | 186 | |
| chr3:160,398,871–160,400,586 | 12.7 kb | Distal (>10kb) Multiome | 790 | |
| chr3:160,400,667–160,401,119 | 3.4 kb | Proximal (<10kb) | 316 | |
| chr3:160,413,716–160,413,937 | 9.2 kb | Proximal (<10kb) | 183 | |
| chr3:160,436,565–160,436,816 | 7.8 kb | Proximal (<10kb) | 36 | |
| chr3:160,448,903–160,450,623 | 37.9 kb | Distal (>10kb) Multiome | 864 | |
| chr3:160,564,297–160,566,417 | 153.6 kb | Distal (>10kb) Multiome | 933 | |
| chr3:160,676,210–160,677,318 | 264.7 kb | Distal (>10kb) Multiome | 203 |
Genomic view of the SMC4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.