Enables protein homodimerization activity and protein serine/threonine kinase activity. Involved in several processes, including cytoplasmic microtubule organization; protein autophosphorylation; and regulation of focal adhesion assembly. Located in perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SLK. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLK upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLK, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:103,692,163–103,693,782 | 274.8 kb | Distal (>10kb) Multiome | 288 | |
| chr10:103,771,858–103,772,878 | 194.7 kb | Distal (>10kb) Multiome | 532 | |
| chr10:103,829,792–103,830,463 | 137.1 kb | Distal (>10kb) Multiome | 65 | |
| chr10:103,836,976–103,837,450 | 130.0 kb | Distal (>10kb) Multiome | 52 | |
| chr10:103,839,572–103,841,382 | 126.8 kb | Distal (>10kb) Multiome | 306 | |
| chr10:103,854,330–103,856,292 | 111.5 kb | Distal (>10kb) Multiome | 649 | |
| chr10:103,917,536–103,919,139 | 48.8 kb | Distal (>10kb) Multiome | 926 | |
| chr10:103,966,618–103,967,712 | 34 bp | At TSS Multiome | 758 | |
| chr10:104,045,227–104,046,125 | 78.4 kb | Distal (>10kb) Multiome | 116 | |
| chr10:104,057,535–104,058,241 | 90.7 kb | Distal (>10kb) Multiome | 66 | |
| chr10:104,120,766–104,122,782 | 154.8 kb | Distal (>10kb) Multiome | 959 | |
| chr10:104,155,284–104,156,268 | 188.7 kb | Distal (>10kb) Multiome | 175 | |
| chr10:104,231,576–104,232,903 | 265.2 kb | Distal (>10kb) Multiome | 777 | |
| chr10:104,252,389–104,254,221 | 286.2 kb | Distal (>10kb) Multiome | 583 | |
| chr10:104,254,370–104,255,379 | 287.7 kb | Distal (>10kb) Multiome | 714 |
Genomic view of the SLK locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.