Predicted to enable ATP binding activity. Predicted to be involved in cell differentiation. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SLFN5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLFN5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLFN5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:34,961,027–34,961,847 | 281.6 kb | Distal (>10kb) Multiome | 793 | |
| chr17:34,980,134–34,981,317 | 262.4 kb | Distal (>10kb) Multiome | 855 | |
| chr17:35,063,589–35,064,217 | 179.3 kb | Distal (>10kb) Multiome | 813 | |
| chr17:35,088,426–35,090,139 | 153.8 kb | Distal (>10kb) Multiome | 805 | |
| chr17:35,119,302–35,120,200 | 123.3 kb | Distal (>10kb) Multiome | 761 | |
| chr17:35,141,908–35,142,655 | 100.8 kb | Distal (>10kb) Multiome | 873 | |
| chr17:35,242,191–35,243,858 | 176 bp | At TSS Multiome | 590 | |
| chr17:35,244,358–35,244,776 | 1.3 kb | Proximal (<10kb) | 289 | |
| chr17:35,312,777–35,313,483 | 69.9 kb | Distal (>10kb) Multiome | 263 | |
| chr17:35,448,264–35,448,971 | 205.6 kb | Distal (>10kb) Multiome | 350 | |
| chr17:35,460,343–35,460,836 | 217.6 kb | Distal (>10kb) Multiome | 174 |
Genomic view of the SLFN5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.