Enables ubiquitin protein ligase binding activity. Involved in several processes, including positive regulation of cellular component organization; positive regulation of double-strand break repair; and protein localization to site of double-strand break. Located in PML body; chromatin; and site of double-strand break. Implicated in mosaic variegated aneuploidy syndrome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SLF2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLF2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLF2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:100,654,597–100,655,452 | 257.9 kb | Distal (>10kb) Multiome | 300 | |
| chr10:100,656,014–100,657,003 | 256.3 kb | Distal (>10kb) Multiome | 310 | |
| chr10:100,670,865–100,671,507 | 241.9 kb | Distal (>10kb) Multiome | 364 | |
| chr10:100,680,805–100,681,542 | 232.0 kb | Distal (>10kb) Multiome | 636 | |
| chr10:100,715,555–100,715,963 | 197.1 kb | Distal (>10kb) Multiome | 117 | |
| chr10:100,729,074–100,730,178 | 183.5 kb | Distal (>10kb) Multiome | 304 | |
| chr10:100,739,174–100,740,373 | 173.2 kb | Distal (>10kb) Multiome | 205 | |
| chr10:100,744,447–100,746,357 | 167.6 kb | Distal (>10kb) Multiome | 379 | |
| chr10:100,760,518–100,761,080 | 152.1 kb | Distal (>10kb) Multiome | 105 | |
| chr10:100,787,902–100,788,519 | 124.8 kb | Distal (>10kb) Multiome | 52 | |
| chr10:100,826,838–100,828,148 | 85.0 kb | Distal (>10kb) Multiome | 327 | |
| chr10:100,912,455–100,913,519 | 67 bp | At TSS Multiome | 906 | |
| chr10:100,968,950–100,970,567 | 56.4 kb | Distal (>10kb) Multiome | 681 | |
| chr10:100,987,003–100,987,794 | 74.5 kb | Distal (>10kb) Multiome | 786 | |
| chr10:100,996,424–100,998,696 | 84.0 kb | Distal (>10kb) Multiome | 945 | |
| chr10:100,998,810–101,000,165 | 86.6 kb | Distal (>10kb) Multiome | 845 | |
| chr10:101,018,377–101,019,461 | 106.1 kb | Distal (>10kb) Multiome | 654 | |
| chr10:101,030,588–101,032,521 | 118.2 kb | Distal (>10kb) Multiome | 613 | |
| chr10:101,042,527–101,043,387 | 129.9 kb | Distal (>10kb) Multiome | 655 | |
| chr10:101,048,051–101,048,547 | 135.3 kb | Distal (>10kb) Multiome | 87 | |
| chr10:101,049,966–101,050,753 | 137.4 kb | Distal (>10kb) Multiome | 412 | |
| chr10:101,060,073–101,063,211 | 149.8 kb | Distal (>10kb) Multiome | 1124 | |
| chr10:101,066,181–101,066,983 | 153.5 kb | Distal (>10kb) Multiome | 734 | |
| chr10:101,067,105–101,068,123 | 154.9 kb | Distal (>10kb) Multiome | 643 | |
| chr10:101,095,368–101,096,269 | 182.7 kb | Distal (>10kb) Multiome | 326 | |
| chr10:101,131,094–101,132,387 | 218.4 kb | Distal (>10kb) Multiome | 289 | |
| chr10:101,139,407–101,140,520 | 226.8 kb | Distal (>10kb) Multiome | 158 | |
| chr10:101,161,678–101,162,270 | 248.9 kb | Distal (>10kb) Multiome | 336 |
Genomic view of the SLF2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.