Enables several functions, including neutral L-amino acid transmembrane transporter activity; protein heterodimerization activity; and secondary active transmembrane transporter activity. Involved in L-alanine import across plasma membrane; L-leucine import across plasma membrane; and thyroid hormone transport. Located in basolateral plasma membrane and microvillus membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SLC7A8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC7A8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC7A8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:22,882,594–22,883,886 | 300.4 kb | Distal (>10kb) Multiome | 289 | |
| chr14:22,886,371–22,887,824 | 296.4 kb | Distal (>10kb) Multiome | 639 | |
| chr14:22,918,527–22,919,975 | 264.3 kb | Distal (>10kb) Multiome | 641 | |
| chr14:22,928,961–22,930,849 | 254.1 kb | Distal (>10kb) Multiome | 1108 | |
| chr14:22,956,530–22,957,512 | 226.6 kb | Distal (>10kb) Multiome | 983 | |
| chr14:22,981,215–22,983,249 | 200.9 kb | Distal (>10kb) Multiome | 935 | |
| chr14:23,006,674–23,007,583 | 176.5 kb | Distal (>10kb) Multiome | 1097 | |
| chr14:23,020,642–23,021,291 | 162.7 kb | Distal (>10kb) Multiome | 148 | |
| chr14:23,101,326–23,101,861 | 82.0 kb | Distal (>10kb) Multiome | 83 | |
| chr14:23,154,159–23,154,639 | 29.2 kb | Distal (>10kb) Multiome | 392 | |
| chr14:23,161,040–23,161,530 | 22.3 kb | Distal (>10kb) Multiome | 397 | |
| chr14:23,173,858–23,174,151 | 9.5 kb | Proximal (<10kb) | 92 | |
| chr14:23,182,495–23,182,942 | 896 bp | At TSS Multiome | 139 | |
| chr14:23,183,191–23,183,788 | at TSS | At TSS | 158 | |
| chr14:23,237,732–23,238,192 | 54.3 kb | Distal (>10kb) Multiome | 536 | |
| chr14:23,285,641–23,286,830 | 102.6 kb | Distal (>10kb) Multiome | 962 | |
| chr14:23,300,944–23,303,002 | 118.0 kb | Distal (>10kb) Multiome | 1096 | |
| chr14:23,306,324–23,307,321 | 123.1 kb | Distal (>10kb) Multiome | 871 | |
| chr14:23,320,558–23,322,196 | 137.6 kb | Distal (>10kb) Multiome | 1090 | |
| chr14:23,351,817–23,353,063 | 169.2 kb | Distal (>10kb) Multiome | 403 | |
| chr14:23,364,202–23,367,105 | 182.8 kb | Distal (>10kb) Multiome | 353 | |
| chr14:23,468,966–23,469,987 | 285.8 kb | Distal (>10kb) Multiome | 955 |
Genomic view of the SLC7A8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.