This gene encodes a member of the solute carrier family 7. The encoded protein is a sodium-independent cationic amino acid transporter. Alternate splicing results in multiple transcripts that encoded the same protein.[provided by RefSeq, May 2010]
Transcription factors with Perturb-seq knockdown data for SLC7A3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC7A3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC7A3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:70,928,659–70,929,038 | 2.1 kb | Proximal (<10kb) | 12 | |
| chrX:70,930,282–70,931,432 | 31 bp | At TSS Multiome | 148 | |
| chrX:71,053,141–71,053,663 | 122.3 kb | Distal (>10kb) Multiome | 90 | |
| chrX:71,067,771–71,068,927 | 137.4 kb | Distal (>10kb) Multiome | 846 | |
| chrX:71,095,671–71,096,651 | 164.9 kb | Distal (>10kb) Multiome | 450 | |
| chrX:71,103,137–71,103,903 | 172.4 kb | Distal (>10kb) Multiome | 375 | |
| chrX:71,181,957–71,182,785 | 251.1 kb | Distal (>10kb) Multiome | 615 |
Genomic view of the SLC7A3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.