This locus encodes a sodium bicarbonate cotransporter. The encoded transmembrane protein appears to transport sodium and bicarbonate ions in a 1:1 ratio, and is thus considered an electroneutral cotransporter. The encoded protein likely plays a critical role in regulation of intracellular pH involved in visual and auditory sensory transmission. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Apr 2012]
Transcription factors with Perturb-seq knockdown data for SLC4A7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC4A7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC4A7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:27,368,750–27,369,718 | 114.9 kb | Distal (>10kb) Multiome | 567 | |
| chr3:27,483,148–27,485,398 | 150 bp | At TSS Multiome | 917 | |
| chr3:27,532,531–27,534,712 | 49.6 kb | Distal (>10kb) Multiome | 739 | |
| chr3:27,632,489–27,633,437 | 148.6 kb | Distal (>10kb) Multiome | 378 | |
| chr3:27,680,718–27,681,875 | 196.8 kb | Distal (>10kb) Multiome | 532 | |
| chr3:27,711,660–27,716,254 | 229.7 kb | Distal (>10kb) Multiome | 783 | |
| chr3:27,720,744–27,724,896 | 238.4 kb | Distal (>10kb) Multiome | 708 | |
| chr3:27,727,875–27,731,045 | 246.0 kb | Distal (>10kb) Multiome | 446 |
Genomic view of the SLC4A7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.