SLC4A2
solute carrier family 4 member 2 | BND3L, HKB3, NBND3, AE2, EPB3L1

This gene encodes a member of the anion exchanger family of membrane transport proteins. The encoded protein regulates intracellular pH, biliary bicarbonate secretion, and chloride uptake. Reduced expression of this gene may be associated with primary biliary cirrhosis (PBC) in human patients, while differential expression of this gene may be associated with malignant hepatocellular carcinoma, colon and gastric cancers. [provided by RefSeq, Nov 2016]

Developmental clusters: GC6
Biological processes 39 terms
amelogenesis (GO:0097186)apical plasma membrane (GO:0016324)apical plasma membrane (GO:0016324)basolateral plasma membrane (GO:0016323)basolateral plasma membrane (GO:0016323)bicarbonate transport (GO:0015701)bicarbonate transport (GO:0015701)chloride transmembrane transport (GO:1902476)chloride:bicarbonate antiporter activity (GO:0140900)chloride:bicarbonate antiporter activity (GO:0140900)chloride:bicarbonate antiporter activity (GO:0140900)digestive tract development (GO:0048565)enzyme binding (GO:0019899)focal adhesion (GO:0005925)membrane (GO:0016020)membrane (GO:0016020)membrane (GO:0016020)monoatomic anion transmembrane transport (GO:0098656)monoatomic anion transmembrane transporter activity (GO:0008509)monoatomic anion transmembrane transporter activity (GO:0008509)monoatomic anion transport (GO:0006820)monoatomic anion transport (GO:0006820)negative regulation of CD8-positive, alpha-beta T cell differentiation (GO:0043377)negative regulation of CD8-positive, alpha-beta T cell proliferation (GO:2000565)osteoclast differentiation (GO:0030316)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)positive regulation of enamel mineralization (GO:0070175)protein binding (GO:0005515)regulation of actin cytoskeleton organization (GO:0032956)regulation of bone resorption (GO:0045124)regulation of intracellular pH (GO:0051453)regulation of intracellular pH (GO:0051453)solute:inorganic anion antiporter activity (GO:0005452)solute:inorganic anion antiporter activity (GO:0005452)spermatogenesis (GO:0007283)transmembrane transport (GO:0055085)transmembrane transporter activity (GO:0022857)
Expression (TPM)
SLC4A2 — as a Regulated Gene

TFs regulating SLC4A2 0 TFs

Transcription factors with Perturb-seq knockdown data for SLC4A2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC4A2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to SLC4A2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC4A2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr7:150,876,795–150,877,753 182.5 kb Distal (>10kb) Multiome 396
chr7:150,973,967–150,975,352 84.8 kb Distal (>10kb) Multiome 572
chr7:150,977,414–150,979,693 81.2 kb Distal (>10kb) Multiome 629
chr7:150,988,543–150,989,168 70.8 kb Distal (>10kb) Multiome 348
chr7:151,007,679–151,009,192 50.9 kb Distal (>10kb) Multiome 693
chr7:151,012,895–151,014,461 45.7 kb Distal (>10kb) Multiome 414
chr7:151,017,863–151,019,302 41.2 kb Distal (>10kb) Multiome 677
chr7:151,026,724–151,029,117 31.1 kb Distal (>10kb) Multiome 1003
chr7:151,050,894–151,051,476 8.3 kb Proximal (<10kb) Multiome 289
chr7:151,056,786–151,057,165 2.4 kb Proximal (<10kb) 130
chr7:151,057,294–151,063,500 73 bp At TSS Multiome 1138
chr7:151,080,217–151,081,897 21.3 kb Distal (>10kb) Multiome 909
chr7:151,083,053–151,083,998 23.9 kb Distal (>10kb) Multiome 581
chr7:151,085,505–151,086,758 26.6 kb Distal (>10kb) Multiome 774
chr7:151,110,933–151,111,501 51.6 kb Distal (>10kb) Multiome 365
chr7:151,114,416–151,115,951 55.9 kb Distal (>10kb) Multiome 279
chr7:151,123,775–151,124,402 64.5 kb Distal (>10kb) Multiome 399
chr7:151,125,352–151,126,446 66.3 kb Distal (>10kb) Multiome 283
chr7:151,166,900–151,168,657 108.7 kb Distal (>10kb) Multiome 533
chr7:151,172,589–151,173,067 113.2 kb Distal (>10kb) Multiome 592
chr7:151,226,743–151,227,948 167.8 kb Distal (>10kb) Multiome 820
chr7:151,232,039–151,233,087 172.9 kb Distal (>10kb) Multiome 692
chr7:151,244,849–151,245,940 186.0 kb Distal (>10kb) Multiome 325
chr7:151,247,809–151,249,951 189.2 kb Distal (>10kb) Multiome 522
chr7:151,251,506–151,252,414 192.4 kb Distal (>10kb) Multiome 448
chr7:151,259,810–151,260,360 200.5 kb Distal (>10kb) Multiome 135
chr7:151,275,718–151,276,602 216.7 kb Distal (>10kb) Multiome 99
chr7:151,276,919–151,277,487 217.6 kb Distal (>10kb) Multiome 367
chr7:151,303,363–151,304,005 244.1 kb Distal (>10kb) Multiome 458
chr7:151,306,906–151,307,424 247.5 kb Distal (>10kb) Multiome 60
chr7:151,341,187–151,342,118 282.1 kb Distal (>10kb) Multiome 757

Genome Browser

Genomic view of the SLC4A2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr7:150,866,795 – 151,352,118
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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