The protein encoded by this gene is a member of a transmembrane protein family that transports small molecules across membranes. The encoded protein has been found in lysosomal membranes, where it can transport catabolites from the lysosomes to the cytoplasm. This protein has been shown to be an effective transporter of the cytotoxic drug maytansine, which is used in antibody-based targeting of cancer cells. [provided by RefSeq, Dec 2016]
Transcription factors with Perturb-seq knockdown data for SLC46A3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC46A3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC46A3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:28,493,679–28,495,839 | 223.7 kb | Distal (>10kb) Multiome | 388 | |
| chr13:28,532,198–28,533,247 | 186.2 kb | Distal (>10kb) Multiome | 397 | |
| chr13:28,545,399–28,546,237 | 173.0 kb | Distal (>10kb) Multiome | 265 | |
| chr13:28,658,912–28,659,587 | 59.9 kb | Distal (>10kb) Multiome | 797 | |
| chr13:28,684,201–28,684,881 | 34.4 kb | Distal (>10kb) Multiome | 106 | |
| chr13:28,704,351–28,704,874 | 14.4 kb | Distal (>10kb) Multiome | 44 | |
| chr13:28,716,279–28,716,910 | 2.3 kb | Proximal (<10kb) Multiome | 277 | |
| chr13:28,718,504–28,719,560 | 42 bp | At TSS Multiome | 517 | |
| chr13:28,819,363–28,820,845 | 101.0 kb | Distal (>10kb) Multiome | 339 |
Genomic view of the SLC46A3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.