Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in plasma membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SLC44A3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC44A3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC44A3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:94,540,914–94,542,577 | 278.5 kb | Distal (>10kb) Multiome HiCAR | 726 | |
| chr1:94,570,815–94,571,430 | 249.2 kb | Distal (>10kb) Multiome | 129 | |
| chr1:94,572,275–94,573,057 | 247.7 kb | Distal (>10kb) Multiome | 73 | |
| chr1:94,657,564–94,658,605 | 162.2 kb | Distal (>10kb) Multiome | 208 | |
| chr1:94,819,759–94,820,829 | 16 bp | At TSS Multiome | 576 | |
| chr1:94,854,217–94,855,200 | 34.3 kb | Distal (>10kb) Multiome | 530 | |
| chr1:94,925,541–94,928,082 | 106.9 kb | Distal (>10kb) Multiome | 926 | |
| chr1:95,072,438–95,073,470 | 252.5 kb | Distal (>10kb) Multiome | 851 | |
| chr1:95,116,608–95,118,188 | 297.0 kb | Distal (>10kb) Multiome | 748 |
Genomic view of the SLC44A3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.