Enables choline transmembrane transporter activity and ethanolamine transmembrane transporter activity. Involved in choline transport; ethanolamine transport; and transmembrane transport. Located in several cellular components, including cytosol; mitochondrial outer membrane; and nucleoplasm. Implicated in high grade glioma. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SLC44A1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC44A1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC44A1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:104,885,889–104,886,798 | 358.4 kb | Distal (>10kb) Multiome HiCAR | 467 | |
| chr9:104,926,377–104,928,757 | 318.0 kb | Distal (>10kb) Multiome HiCAR | 898 | |
| chr9:104,961,289–104,961,961 | 283.2 kb | Distal (>10kb) Multiome | 296 | |
| chr9:104,967,924–104,969,360 | 276.2 kb | Distal (>10kb) Multiome | 657 | |
| chr9:104,990,922–104,992,163 | 252.9 kb | Distal (>10kb) Multiome | 685 | |
| chr9:104,993,121–104,994,152 | 251.0 kb | Distal (>10kb) Multiome | 314 | |
| chr9:105,104,550–105,105,176 | 139.9 kb | Distal (>10kb) Multiome | 81 | |
| chr9:105,121,705–105,122,364 | 122.7 kb | Distal (>10kb) Multiome | 74 | |
| chr9:105,138,128–105,139,010 | 106.1 kb | Distal (>10kb) Multiome | 255 | |
| chr9:105,241,453–105,241,654 | 3.0 kb | Proximal (<10kb) | 43 | |
| chr9:105,241,769–105,241,932 | 2.7 kb | Proximal (<10kb) | 71 | |
| chr9:105,244,049–105,245,808 | 583 bp | At TSS Multiome | 1131 | |
| chr9:105,302,583–105,303,463 | 58.3 kb | Distal (>10kb) Multiome | 70 | |
| chr9:105,447,454–105,448,988 | 203.4 kb | Distal (>10kb) Multiome | 800 | |
| chr9:105,458,358–105,459,172 | 214.0 kb | Distal (>10kb) Multiome | 80 |
Genomic view of the SLC44A1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.