SLC39A9
solute carrier family 39 member 9 | FLJ11274, ZIP9

Enables G protein-coupled receptor activity; androgen binding activity; and zinc efflux transmembrane transporter activity. Involved in intracellular zinc ion homeostasis; regulation of vascular endothelial cell proliferation; and zinc ion transmembrane transport. Located in several cellular components, including mitochondrial membrane; perinuclear region of cytoplasm; and trans-Golgi network. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-2 Developmental clusters: GC1
Biological processes 29 terms
G protein-coupled receptor activity (GO:0004930)G protein-coupled receptor signaling pathway (GO:0007186)Golgi apparatus (GO:0005794)androgen binding (GO:0005497)bicellular tight junction assembly (GO:0070830)intracellular zinc ion homeostasis (GO:0006882)membrane (GO:0016020)metal ion transmembrane transporter activity (GO:0046873)metal ion transport (GO:0030001)mitochondrial membrane (GO:0031966)mitochondrion (GO:0005739)mitochondrion (GO:0005739)nucleus (GO:0005634)nucleus (GO:0005634)perinuclear region of cytoplasm (GO:0048471)perinuclear region of cytoplasm (GO:0048471)plasma membrane (GO:0005886)plasma membrane (GO:0005886)protein binding (GO:0005515)regulation of cellular response to testosterone stimulus (GO:2000654)regulation of cellular response to testosterone stimulus (GO:2000654)regulation of vascular endothelial cell proliferation (GO:1905562)trans-Golgi network (GO:0005802)transmembrane transport (GO:0055085)zinc efflux transmembrane transporter activity (GO:0022883)zinc ion transmembrane transport (GO:0071577)zinc ion transmembrane transporter activity (GO:0005385)zinc ion transmembrane transporter activity (GO:0005385)zinc ion transport (GO:0006829)
Expression (TPM)
SLC39A9 — as a Regulated Gene

TFs regulating SLC39A9 0 TFs

Transcription factors with Perturb-seq knockdown data for SLC39A9. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC39A9 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to SLC39A9

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC39A9, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr14:69,129,353–69,129,859 268.9 kb Distal (>10kb) Multiome 260
chr14:69,149,737–69,150,445 248.3 kb Distal (>10kb) Multiome 70
chr14:69,151,308–69,153,780 246.7 kb Distal (>10kb) Multiome 936
chr14:69,191,332–69,192,132 206.8 kb Distal (>10kb) Multiome 977
chr14:69,259,475–69,261,593 138.6 kb Distal (>10kb) Multiome 477
chr14:69,397,842–69,399,035 128 bp At TSS Multiome 926
chr14:69,483,950–69,485,210 86.2 kb Distal (>10kb) Multiome 334
chr14:69,547,663–69,548,492 149.7 kb Distal (>10kb) Multiome 213
chr14:69,561,722–69,562,330 163.7 kb Distal (>10kb) Multiome 67
chr14:69,571,579–69,572,640 173.8 kb Distal (>10kb) Multiome 300
chr14:69,574,502–69,574,973 176.4 kb Distal (>10kb) Multiome 302
chr14:69,611,065–69,612,800 213.2 kb Distal (>10kb) Multiome 628

Genome Browser

Genomic view of the SLC39A9 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr14:69,119,353 – 69,622,800
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
Huangfu Lab · Publications · Resources · Contact