Enables neutral L-amino acid:sodium symporter activity. Involved in several processes, including cellular response to arsenite(3-); neutral amino acid transport; and positive regulation of RNA splicing. Located in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SLC38A2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC38A2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC38A2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:46,267,263–46,270,142 | 103.7 kb | Distal (>10kb) Multiome | 1114 | |
| chr12:46,370,990–46,374,187 | 100 bp | At TSS Multiome | 1163 | |
| chr12:46,382,727–46,384,328 | 10.7 kb | Distal (>10kb) Multiome | 1071 | |
| chr12:46,406,190–46,407,087 | 33.8 kb | Distal (>10kb) Multiome | 143 |
Genomic view of the SLC38A2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.