Amino acid transporters play essential roles in the uptake of nutrients, production of energy, chemical metabolism, detoxification, and neurotransmitter cycling. SLC38A1 is an important transporter of glutamine, an intermediate in the detoxification of ammonia and the production of urea. Glutamine serves as a precursor for the synaptic transmitter, glutamate (Gu et al., 2001 [PubMed 11325958]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for SLC38A1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC38A1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC38A1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:45,989,594–45,992,639 | 278.3 kb | Distal (>10kb) Multiome | 1242 | |
| chr12:46,267,263–46,270,142 | 61 bp | At TSS Multiome | 1114 | |
| chr12:46,370,990–46,374,187 | 103.8 kb | Distal (>10kb) Multiome | 1163 | |
| chr12:46,382,727–46,384,328 | 114.4 kb | Distal (>10kb) Multiome | 1071 | |
| chr12:46,406,190–46,407,087 | 137.5 kb | Distal (>10kb) Multiome | 143 | |
| chr12:47,705,453–47,706,210 | 1436.9 kb | Distal (>10kb) Multiome HiCAR | 859 |
Genomic view of the SLC38A1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.