This gene regulates glucose-6-phosphate transport from the cytoplasm to the lumen of the endoplasmic reticulum, in order to maintain glucose homeostasis. It also plays a role in ATP-mediated calcium sequestration in the lumen of the endoplasmic reticulum. Mutations in this gene have been associated with various forms of glycogen storage disease. Alternative splicing in this gene results in multiple transcript variants.[provided by RefSeq, Aug 2009]
Transcription factors with Perturb-seq knockdown data for SLC37A4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC37A4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC37A4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:118,789,603–118,790,362 | 241.0 kb | Distal (>10kb) Multiome | 293 | |
| chr11:118,790,448–118,793,117 | 237.9 kb | Distal (>10kb) Multiome | 958 | |
| chr11:118,907,074–118,907,685 | 123.6 kb | Distal (>10kb) Multiome | 491 | |
| chr11:118,909,181–118,909,816 | 121.5 kb | Distal (>10kb) Multiome | 326 | |
| chr11:118,909,976–118,911,609 | 120.2 kb | Distal (>10kb) Multiome | 652 | |
| chr11:118,911,717–118,912,963 | 118.6 kb | Distal (>10kb) Multiome | 689 | |
| chr11:118,916,429–118,917,335 | 113.9 kb | Distal (>10kb) Multiome | 355 | |
| chr11:118,917,640–118,918,851 | 112.4 kb | Distal (>10kb) Multiome | 522 | |
| chr11:118,925,703–118,926,356 | 104.8 kb | Distal (>10kb) Multiome | 595 | |
| chr11:118,927,947–118,930,852 | 101.4 kb | Distal (>10kb) Multiome | 892 | |
| chr11:118,997,538–118,998,797 | 32.8 kb | Distal (>10kb) Multiome | 798 | |
| chr11:119,018,081–119,019,265 | 12.3 kb | Distal (>10kb) Multiome | 897 | |
| chr11:119,028,269–119,028,679 | 2.2 kb | Proximal (<10kb) | 68 | |
| chr11:119,029,885–119,031,330 | 51 bp | At TSS Multiome | 876 | |
| chr11:119,056,436–119,057,778 | 26.4 kb | Distal (>10kb) Multiome | 815 | |
| chr11:119,067,446–119,068,100 | 36.9 kb | Distal (>10kb) Multiome | 762 | |
| chr11:119,084,563–119,085,756 | 54.2 kb | Distal (>10kb) Multiome | 846 | |
| chr11:119,093,969–119,096,070 | 64.7 kb | Distal (>10kb) Multiome | 1046 | |
| chr11:119,101,351–119,102,791 | 71.3 kb | Distal (>10kb) Multiome | 871 | |
| chr11:119,106,906–119,107,993 | 76.5 kb | Distal (>10kb) Multiome | 650 | |
| chr11:119,120,857–119,122,037 | 90.6 kb | Distal (>10kb) Multiome | 787 | |
| chr11:119,144,795–119,145,355 | 114.2 kb | Distal (>10kb) Multiome | 230 | |
| chr11:119,148,816–119,149,933 | 118.7 kb | Distal (>10kb) Multiome | 262 | |
| chr11:119,168,601–119,169,645 | 138.0 kb | Distal (>10kb) Multiome | 794 | |
| chr11:119,205,241–119,207,150 | 175.3 kb | Distal (>10kb) Multiome | 695 | |
| chr11:119,315,017–119,315,819 | 284.5 kb | Distal (>10kb) Multiome | 270 | |
| chr11:119,316,693–119,317,760 | 286.4 kb | Distal (>10kb) Multiome | 463 | |
| chr11:119,320,617–119,321,906 | 290.9 kb | Distal (>10kb) Multiome | 516 |
Genomic view of the SLC37A4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.