SLC36A4 belongs to the SLC36 family of amino acid transporters based on sequence similarity with other family members (e.g., SLC36A1; MIM 606561). SLC36 proteins contain about 500 amino acids and have 9 to 11 transmembrane domains. Unlike other SLC36 family members, which are proton-coupled amino acid transporters, SLC36A4 is a high-affinity/low-capacity non-proton-coupled amino acid transporter (Pillai and Meredith, 2011 [PubMed 21097500]).[supplied by OMIM, Feb 2011]
Transcription factors with Perturb-seq knockdown data for SLC36A4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC36A4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC36A4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:92,931,640–92,932,556 | 265.9 kb | Distal (>10kb) Multiome | 228 | |
| chr11:93,072,600–93,074,654 | 123.8 kb | Distal (>10kb) Multiome | 229 | |
| chr11:93,089,322–93,089,831 | 108.4 kb | Distal (>10kb) Multiome | 129 | |
| chr11:93,116,571–93,117,518 | 81.1 kb | Distal (>10kb) Multiome | 130 | |
| chr11:93,197,175–93,198,389 | 37 bp | At TSS Multiome | 883 | |
| chr11:93,330,006–93,331,029 | 132.6 kb | Distal (>10kb) Multiome | 319 | |
| chr11:93,444,389–93,445,160 | 246.8 kb | Distal (>10kb) Multiome | 173 | |
| chr11:93,661,372–93,662,246 | 463.7 kb | Distal (>10kb) Multiome HiCAR | 1008 |
Genomic view of the SLC36A4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.