Involved in thiamine transport. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SLC35F3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC35F3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC35F3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:233,326,831–233,329,042 | 886.7 kb | Distal (>10kb) Multiome HiCAR | 601 | |
| chr1:234,075,263–234,075,988 | 138.5 kb | Distal (>10kb) Multiome | 61 | |
| chr1:234,092,919–234,093,755 | 120.9 kb | Distal (>10kb) Multiome | 62 | |
| chr1:234,212,827–234,213,050 | 1.2 kb | Proximal (<10kb) | 95 | |
| chr1:234,214,031–234,215,631 | 947 bp | At TSS Multiome | 327 | |
| chr1:234,229,899–234,231,030 | 16.2 kb | Distal (>10kb) Multiome | 183 | |
| chr1:234,261,272–234,262,769 | 47.6 kb | Distal (>10kb) Multiome | 234 | |
| chr1:234,281,735–234,282,611 | 67.9 kb | Distal (>10kb) Multiome | 140 | |
| chr1:234,372,993–234,374,088 | 159.2 kb | Distal (>10kb) Multiome | 1034 | |
| chr1:234,478,073–234,479,488 | 264.7 kb | Distal (>10kb) Multiome | 772 | |
| chr1:234,490,875–234,491,564 | 276.9 kb | Distal (>10kb) Multiome | 380 |
Genomic view of the SLC35F3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.