This gene encodes a member of the triose-phosphate transporter protein family. This gene is regulated by oxygen tension, is induced in hypoxic trophoblast cells, and is overexpressed in ovarian cancer. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been defined on the X chromosome. [provided by RefSeq, Jul 2013]
Transcription factors with Perturb-seq knockdown data for SLC35C2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC35C2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC35C2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:46,089,092–46,090,355 | 274.5 kb | Distal (>10kb) Multiome | 1047 | |
| chr20:46,091,736–46,092,300 | 272.2 kb | Distal (>10kb) Multiome | 38 | |
| chr20:46,117,897–46,118,755 | 246.1 kb | Distal (>10kb) Multiome | 376 | |
| chr20:46,174,457–46,175,011 | 189.7 kb | Distal (>10kb) Multiome | 277 | |
| chr20:46,268,041–46,268,560 | 96.1 kb | Distal (>10kb) Multiome | 82 | |
| chr20:46,307,134–46,307,979 | 57.1 kb | Distal (>10kb) Multiome | 455 | |
| chr20:46,308,245–46,308,857 | 55.8 kb | Distal (>10kb) Multiome | 287 | |
| chr20:46,363,898–46,364,657 | 73 bp | At TSS Multiome | 983 | |
| chr20:46,405,903–46,407,320 | 42.1 kb | Distal (>10kb) Multiome | 946 | |
| chr20:46,459,001–46,459,476 | 94.9 kb | Distal (>10kb) Multiome | 157 | |
| chr20:46,513,244–46,513,752 | 149.2 kb | Distal (>10kb) Multiome | 458 | |
| chr20:46,562,567–46,563,148 | 198.4 kb | Distal (>10kb) Multiome | 483 | |
| chr20:46,583,359–46,584,278 | 219.4 kb | Distal (>10kb) Multiome | 196 | |
| chr20:46,648,981–46,649,761 | 284.9 kb | Distal (>10kb) Multiome | 275 | |
| chr20:46,651,152–46,651,711 | 287.0 kb | Distal (>10kb) Multiome | 558 |
Genomic view of the SLC35C2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.