This gene encodes a member of a family of proteins that function as zinc transporters. This protein can regulate subcellular levels of zinc in the Golgi and vesicles. Expression of this gene is altered in the Alzheimer's disease brain plaques. [provided by RefSeq, Aug 2016]
Transcription factors with Perturb-seq knockdown data for SLC30A6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC30A6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC30A6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:32,009,204–32,011,546 | 155.0 kb | Distal (>10kb) Multiome | 1139 | |
| chr2:32,039,227–32,040,182 | 126.1 kb | Distal (>10kb) Multiome | 881 | |
| chr2:32,062,443–32,064,607 | 102.3 kb | Distal (>10kb) Multiome | 1021 | |
| chr2:32,165,199–32,166,316 | 107 bp | At TSS Multiome | 991 | |
| chr2:32,277,550–32,278,517 | 112.1 kb | Distal (>10kb) Multiome | 913 | |
| chr2:32,356,410–32,358,403 | 191.2 kb | Distal (>10kb) Multiome | 1140 | |
| chr2:32,381,392–32,382,477 | 215.8 kb | Distal (>10kb) Multiome | 98 |
Genomic view of the SLC30A6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.