This gene encodes a member of the SLC29A/ENT transporter protein family. The encoded membrane protein catalyzes the reuptake of monoamines into presynaptic neurons, thus determining the intensity and duration of monoamine neural signaling. It has been shown to transport several compounds, including serotonin, dopamine, and the neurotoxin 1-methyl-4-phenylpyridinium. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Transcription factors with Perturb-seq knockdown data for SLC29A4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC29A4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC29A4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:5,045,501–5,046,448 | 237.1 kb | Distal (>10kb) Multiome | 594 | |
| chr7:5,189,698–5,190,896 | 92.7 kb | Distal (>10kb) Multiome | 725 | |
| chr7:5,240,214–5,240,895 | 42.5 kb | Distal (>10kb) Multiome | 613 | |
| chr7:5,282,868–5,283,241 | at TSS | At TSS | 46 | |
| chr7:5,285,025–5,285,231 | 2.1 kb | Proximal (<10kb) | 132 | |
| chr7:5,296,049–5,297,455 | 13.8 kb | Distal (>10kb) Multiome | 191 | |
| chr7:5,401,296–5,401,948 | 118.6 kb | Distal (>10kb) Multiome | 104 | |
| chr7:5,406,932–5,408,289 | 124.7 kb | Distal (>10kb) Multiome | 281 | |
| chr7:5,412,740–5,413,653 | 130.4 kb | Distal (>10kb) Multiome | 341 | |
| chr7:5,417,700–5,419,525 | 136.0 kb | Distal (>10kb) Multiome | 714 | |
| chr7:5,423,102–5,425,439 | 141.1 kb | Distal (>10kb) Multiome | 834 | |
| chr7:5,426,416–5,429,142 | 144.0 kb | Distal (>10kb) Multiome | 1072 | |
| chr7:5,450,591–5,451,143 | 167.9 kb | Distal (>10kb) Multiome | 306 | |
| chr7:5,486,725–5,487,360 | 204.1 kb | Distal (>10kb) Multiome HiCAR | 621 | |
| chr7:5,494,650–5,495,099 | 211.9 kb | Distal (>10kb) Multiome | 515 | |
| chr7:5,513,480–5,514,175 | 230.9 kb | Distal (>10kb) Multiome | 815 | |
| chr7:5,524,684–5,527,073 | 243.7 kb | Distal (>10kb) Multiome | 736 | |
| chr7:5,529,088–5,532,313 | 247.0 kb | Distal (>10kb) Multiome | 1081 | |
| chr7:5,554,765–5,555,676 | 272.3 kb | Distal (>10kb) Multiome | 643 | |
| chr7:5,555,801–5,557,053 | 273.7 kb | Distal (>10kb) Multiome | 807 | |
| chr7:5,558,744–5,559,347 | 276.1 kb | Distal (>10kb) Multiome | 525 | |
| chr7:5,562,000–5,564,024 | 279.1 kb | Distal (>10kb) Multiome | 859 | |
| chr7:5,569,367–5,570,943 | 287.3 kb | Distal (>10kb) Multiome | 694 | |
| chr7:5,574,238–5,575,433 | 292.0 kb | Distal (>10kb) Multiome | 447 |
Genomic view of the SLC29A4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.