This gene encodes a member of the fatty acid transport protein family (FATP). FATPs are involved in the uptake of long-chain fatty acids and have unique expression patterns. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for SLC27A6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC27A6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC27A6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:127,517,064–127,518,431 | 1020.3 kb | Distal (>10kb) Multiome HiCAR | 880 | |
| chr5:128,200,690–128,202,024 | 336.5 kb | Distal (>10kb) Multiome HiCAR | 518 | |
| chr5:128,536,194–128,539,650 | 466 bp | At TSS Multiome | 630 | |
| chr5:128,546,603–128,547,415 | 9.0 kb | Proximal (<10kb) Multiome | 192 | |
| chr5:128,962,122–128,962,508 | 3.0 kb | Proximal (<10kb) | 2 | |
| chr5:128,964,903–128,966,694 | 427.3 kb | Distal (>10kb) Multiome | 511 | |
| chr5:129,094,005–129,095,887 | 556.6 kb | Distal (>10kb) Multiome | 998 |
Genomic view of the SLC27A6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.