SLC25A37 is a solute carrier localized in the mitochondrial inner membrane. It functions as an essential iron importer for the synthesis of mitochondrial heme and iron-sulfur clusters (summary by Chen et al., 2009 [PubMed 19805291]).[supplied by OMIM, Jan 2011]
Transcription factors with Perturb-seq knockdown data for SLC25A37. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC25A37 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC25A37, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:23,246,206–23,247,324 | 282.3 kb | Distal (>10kb) Multiome | 941 | |
| chr8:23,287,908–23,288,715 | 240.8 kb | Distal (>10kb) Multiome | 853 | |
| chr8:23,403,157–23,405,109 | 124.8 kb | Distal (>10kb) Multiome | 425 | |
| chr8:23,451,094–23,451,922 | 77.5 kb | Distal (>10kb) Multiome | 182 | |
| chr8:23,457,148–23,458,219 | 71.3 kb | Distal (>10kb) Multiome | 736 | |
| chr8:23,486,400–23,487,438 | 42.1 kb | Distal (>10kb) Multiome | 134 | |
| chr8:23,523,307–23,523,544 | 5.4 kb | Proximal (<10kb) | 89 | |
| chr8:23,527,665–23,528,081 | 873 bp | At TSS | 217 | |
| chr8:23,528,169–23,530,101 | 123 bp | At TSS Multiome | 832 | |
| chr8:23,682,166–23,683,403 | 154.0 kb | Distal (>10kb) Multiome | 655 | |
| chr8:23,706,237–23,707,411 | 177.9 kb | Distal (>10kb) Multiome | 215 | |
| chr8:23,709,392–23,710,292 | 181.0 kb | Distal (>10kb) Multiome | 98 | |
| chr8:23,714,334–23,715,166 | 185.8 kb | Distal (>10kb) Multiome | 334 | |
| chr8:23,785,542–23,786,124 | 256.9 kb | Distal (>10kb) Multiome | 146 |
Genomic view of the SLC25A37 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.