Predicted to enable ferrous iron transmembrane transporter activity. Predicted to be involved in iron import into the mitochondrion. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SLC25A28. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC25A28 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC25A28, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:99,357,908–99,359,626 | 261.3 kb | Distal (>10kb) Multiome | 160 | |
| chr10:99,370,159–99,370,697 | 250.0 kb | Distal (>10kb) Multiome | 14 | |
| chr10:99,430,207–99,431,536 | 189.6 kb | Distal (>10kb) Multiome | 882 | |
| chr10:99,519,844–99,520,769 | 100.2 kb | Distal (>10kb) Multiome | 331 | |
| chr10:99,522,567–99,524,013 | 97.2 kb | Distal (>10kb) Multiome | 201 | |
| chr10:99,527,131–99,527,911 | 92.9 kb | Distal (>10kb) Multiome | 89 | |
| chr10:99,532,575–99,533,287 | 87.5 kb | Distal (>10kb) Multiome | 160 | |
| chr10:99,534,863–99,536,063 | 85.0 kb | Distal (>10kb) Multiome | 193 | |
| chr10:99,536,574–99,538,002 | 83.4 kb | Distal (>10kb) Multiome | 279 | |
| chr10:99,612,332–99,612,540 | 7.9 kb | Proximal (<10kb) | 175 | |
| chr10:99,619,825–99,621,725 | 277 bp | At TSS Multiome | 1070 | |
| chr10:99,658,847–99,660,052 | 39.0 kb | Distal (>10kb) Multiome | 728 | |
| chr10:99,731,799–99,732,929 | 111.8 kb | Distal (>10kb) Multiome | 941 | |
| chr10:99,913,671–99,914,615 | 293.6 kb | Distal (>10kb) Multiome | 256 |
Genomic view of the SLC25A28 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.