SLC25A26

solute carrier family 25 member 26 | SAMC

This gene is a member of the mitochondrial carrier family which includes nuclear-encoded transporters localized on the inner mitochondrial membranes. Members of the family transport important small molecules across the mitochondrial inner membrane. This protein is involved in the transport of S-adenosylmethionine (SAM) into the mitochondria. Mutations in this gene are associated with combined oxidative phosphorylation deficiency 28. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2017]

Member of: DE-2 DE-2.2

Biological processes 17 terms

L-alpha-amino acid transmembrane transport (GO:1902475)S-adenosyl-L-methionine transmembrane transporter activity (GO:0000095)S-adenosyl-L-methionine transmembrane transporter activity (GO:0000095)S-adenosyl-L-methionine transmembrane transporter activity (GO:0000095)S-adenosyl-L-methionine transport (GO:0015805)S-adenosyl-L-methionine:S-adenosyl-L-homocysteine antiporter activity (GO:0180003)amine transport (GO:0015837)macromolecule methylation (GO:0043414)mitochondrial S-adenosyl-L-methionine transmembrane transport (GO:1990543)mitochondrial inner membrane (GO:0005743)mitochondrial inner membrane (GO:0005743)mitochondrial inner membrane (GO:0005743)mitochondrial inner membrane (GO:0005743)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion (GO:0005739)purine nucleoside transmembrane transport (GO:0015860)

Expression (TPM)

TFs regulating SLC25A26 0 TFs

Transcription factors with Perturb-seq knockdown data for SLC25A26. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC25A26 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to SLC25A26

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC25A26, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr3:65,950,226–65,950,881	270.5 kb	Distal (>10kb) Multiome	135
chr3:65,953,020–65,953,813	267.4 kb	Distal (>10kb) Multiome	435
chr3:66,037,331–66,039,992	182.0 kb	Distal (>10kb) Multiome	825
chr3:66,220,628–66,221,378	44 bp	At TSS Multiome	818
chr3:66,415,883–66,417,138	195.7 kb	Distal (>10kb) Multiome	115
chr3:66,441,917–66,443,468	221.4 kb	Distal (>10kb) Multiome	428
chr3:66,452,752–66,454,355	232.9 kb	Distal (>10kb) Multiome	257
chr3:66,499,991–66,502,058	280.2 kb	Distal (>10kb) Multiome	746

Genome Browser

Genomic view of the SLC25A26 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.