SLC25A21 is a homolog of the S. cerevisiae ODC proteins, mitochondrial carriers that transport C5-C7 oxodicarboxylates across inner mitochondrial membranes. One of the species transported by ODC is 2-oxoadipate, a common intermediate in the catabolism of lysine, tryptophan, and hydroxylysine in mammals. Within mitochondria, 2-oxoadipate is converted into acetyl-CoA.[supplied by OMIM, Apr 2004]
Transcription factors with Perturb-seq knockdown data for SLC25A21. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC25A21 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC25A21, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:36,646,734–36,648,858 | 524.3 kb | Distal (>10kb) Multiome HiCAR | 499 | |
| chr14:36,655,705–36,656,663 | 516.2 kb | Distal (>10kb) Multiome HiCAR | 313 | |
| chr14:37,167,668–37,168,127 | 4.5 kb | Proximal (<10kb) Multiome | 132 | |
| chr14:37,171,766–37,172,888 | 130 bp | At TSS Multiome | 1033 | |
| chr14:37,197,407–37,198,571 | 25.5 kb | Distal (>10kb) Multiome | 891 |
Genomic view of the SLC25A21 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.