This gene product is one of several closely related mitochondrial-membrane carrier proteins that shuttle substrates between cytosol and the intramitochondrial matrix space. This protein mediates the transport of acylcarnitines into mitochondrial matrix for their oxidation by the mitochondrial fatty acid-oxidation pathway. Mutations in this gene are associated with carnitine-acylcarnitine translocase deficiency, which can cause a variety of pathological conditions such as hypoglycemia, cardiac arrest, hepatomegaly, hepatic dysfunction and muscle weakness, and is usually lethal in new born and infants. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for SLC25A20. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC25A20 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC25A20, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:48,608,816–48,610,628 | 289.3 kb | Distal (>10kb) Multiome | 850 | |
| chr3:48,634,696–48,636,251 | 263.3 kb | Distal (>10kb) Multiome | 898 | |
| chr3:48,655,787–48,657,257 | 242.5 kb | Distal (>10kb) Multiome | 438 | |
| chr3:48,661,275–48,664,636 | 234.9 kb | Distal (>10kb) Multiome | 1248 | |
| chr3:48,685,362–48,686,531 | 213.0 kb | Distal (>10kb) Multiome | 770 | |
| chr3:48,716,958–48,717,863 | 181.6 kb | Distal (>10kb) Multiome | 634 | |
| chr3:48,847,059–48,848,224 | 51.1 kb | Distal (>10kb) Multiome | 772 | |
| chr3:48,898,423–48,899,110 | 10 bp | At TSS Multiome | 739 | |
| chr3:48,918,234–48,919,609 | 19.9 kb | Distal (>10kb) Multiome | 877 | |
| chr3:48,989,537–48,991,069 | 91.1 kb | Distal (>10kb) Multiome | 552 | |
| chr3:49,006,738–49,008,496 | 109.0 kb | Distal (>10kb) Multiome | 955 | |
| chr3:49,017,789–49,018,870 | 119.5 kb | Distal (>10kb) Multiome | 780 | |
| chr3:49,020,066–49,022,597 | 122.9 kb | Distal (>10kb) Multiome | 1064 | |
| chr3:49,028,856–49,029,800 | 130.5 kb | Distal (>10kb) Multiome | 974 | |
| chr3:49,093,005–49,094,956 | 195.4 kb | Distal (>10kb) Multiome | 944 | |
| chr3:49,104,279–49,105,309 | 205.9 kb | Distal (>10kb) Multiome | 712 | |
| chr3:49,120,575–49,121,282 | 222.0 kb | Distal (>10kb) Multiome | 765 | |
| chr3:49,132,603–49,133,965 | 234.8 kb | Distal (>10kb) Multiome | 652 | |
| chr3:49,166,057–49,166,586 | 267.4 kb | Distal (>10kb) Multiome | 622 | |
| chr3:49,170,896–49,171,950 | 272.5 kb | Distal (>10kb) Multiome | 781 |
Genomic view of the SLC25A20 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.