This gene is a member of the mitochondrial carrier family. The encoded protein transports ornithine across the inner mitochondrial membrane from the cytosol to the mitochondrial matrix. The protein is an essential component of the urea cycle, and functions in ammonium detoxification and biosynthesis of the amino acid arginine. Mutations in this gene result in hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome. There is a pseudogene of this locus on the Y chromosome.[provided by RefSeq, May 2009]
Transcription factors with Perturb-seq knockdown data for SLC25A15. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC25A15 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC25A15, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:39,037,483–39,038,865 | 1751.4 kb | Distal (>10kb) Multiome HiCAR | 925 | |
| chr13:40,651,850–40,652,501 | 137.4 kb | Distal (>10kb) Multiome | 187 | |
| chr13:40,663,960–40,667,930 | 122.7 kb | Distal (>10kb) Multiome | 878 | |
| chr13:40,680,324–40,681,411 | 108.6 kb | Distal (>10kb) Multiome | 281 | |
| chr13:40,770,737–40,771,525 | 18.2 kb | Distal (>10kb) Multiome | 1000 | |
| chr13:40,789,168–40,790,225 | 84 bp | At TSS Multiome | 837 | |
| chr13:40,921,270–40,922,017 | 132.2 kb | Distal (>10kb) Multiome | 675 | |
| chr13:41,060,003–41,062,196 | 272.2 kb | Distal (>10kb) Multiome | 1139 | |
| chr13:41,085,849–41,086,392 | 296.6 kb | Distal (>10kb) Multiome | 126 |
Genomic view of the SLC25A15 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.