This gene encodes a member of a family of proteins that translocate small metabolites across the mitochondrial membrane. The encoded protein exchanges dicarboxylates, such as malate and succinate, for phosphate, sulfate, and other small molecules, thereby providing substrates for metabolic processes including the Krebs cycle and fatty acid synthesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]
Transcription factors with Perturb-seq knockdown data for SLC25A10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC25A10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC25A10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:81,481,258–81,481,865 | 230.7 kb | Distal (>10kb) Multiome | 348 | |
| chr17:81,483,927–81,484,829 | 227.8 kb | Distal (>10kb) Multiome | 828 | |
| chr17:81,487,690–81,488,371 | 224.2 kb | Distal (>10kb) Multiome | 721 | |
| chr17:81,511,887–81,515,656 | 197.3 kb | Distal (>10kb) Multiome | 1116 | |
| chr17:81,537,462–81,537,907 | 174.5 kb | Distal (>10kb) Multiome | 282 | |
| chr17:81,551,821–81,553,314 | 159.1 kb | Distal (>10kb) Multiome | 845 | |
| chr17:81,636,404–81,637,301 | 75.2 kb | Distal (>10kb) Multiome | 946 | |
| chr17:81,648,048–81,648,550 | 64.0 kb | Distal (>10kb) Multiome | 88 | |
| chr17:81,652,970–81,653,572 | 59.1 kb | Distal (>10kb) Multiome | 188 | |
| chr17:81,666,251–81,667,166 | 45.6 kb | Distal (>10kb) Multiome | 901 | |
| chr17:81,683,344–81,684,556 | 28.3 kb | Distal (>10kb) Multiome | 926 | |
| chr17:81,702,879–81,703,868 | 8.9 kb | Proximal (<10kb) Multiome | 981 | |
| chr17:81,711,721–81,712,812 | 20 bp | At TSS Multiome | 1056 | |
| chr17:81,832,473–81,833,976 | 121.0 kb | Distal (>10kb) Multiome | 1015 | |
| chr17:81,859,762–81,861,595 | 148.6 kb | Distal (>10kb) Multiome | 1134 | |
| chr17:81,869,000–81,872,289 | 159.1 kb | Distal (>10kb) Multiome | 1136 | |
| chr17:81,891,143–81,892,257 | 179.5 kb | Distal (>10kb) Multiome | 969 | |
| chr17:81,910,443–81,911,980 | 199.3 kb | Distal (>10kb) Multiome | 806 | |
| chr17:81,917,586–81,918,522 | 205.9 kb | Distal (>10kb) Multiome | 619 | |
| chr17:81,926,141–81,929,133 | 215.7 kb | Distal (>10kb) Multiome | 1034 | |
| chr17:81,936,855–81,937,682 | 225.1 kb | Distal (>10kb) Multiome | 854 | |
| chr17:81,976,595–81,978,312 | 265.4 kb | Distal (>10kb) Multiome | 1001 |
Genomic view of the SLC25A10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.