The protein encoded by this gene is a sodium-phosphate symporter that absorbs phosphate from interstitial fluid for use in cellular functions such as metabolism, signal transduction, and nucleic acid and lipid synthesis. The encoded protein is also a retroviral receptor, causing human cells to be susceptible to infection by gibbon ape leukemia virus, simian sarcoma-associated virus, feline leukemia virus subgroup B, and 10A1 murine leukemia virus.[provided by RefSeq, Mar 2011]
Transcription factors with Perturb-seq knockdown data for SLC20A1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC20A1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC20A1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:112,480,926–112,482,608 | 164.8 kb | Distal (>10kb) Multiome | 860 | |
| chr2:112,541,785–112,542,849 | 103.7 kb | Distal (>10kb) Multiome | 1070 | |
| chr2:112,583,940–112,585,172 | 61.4 kb | Distal (>10kb) Multiome | 949 | |
| chr2:112,645,080–112,646,681 | 138 bp | At TSS Multiome | 980 | |
| chr2:112,674,793–112,675,390 | 29.2 kb | Distal (>10kb) Multiome | 54 | |
| chr2:112,726,233–112,727,218 | 80.9 kb | Distal (>10kb) Multiome HiCAR | 667 | |
| chr2:112,763,867–112,765,097 | 118.8 kb | Distal (>10kb) Multiome | 854 | |
| chr2:112,848,882–112,849,414 | 203.2 kb | Distal (>10kb) Multiome | 76 | |
| chr2:112,884,727–112,885,204 | 239.1 kb | Distal (>10kb) Multiome | 294 |
Genomic view of the SLC20A1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.