Lactic acid and pyruvate transport across plasma membranes is catalyzed by members of the proton-linked monocarboxylate transporter (MCT) family, which has been designated solute carrier family-16. Each MCT appears to have slightly different substrate and inhibitor specificities and transport kinetics, which are related to the metabolic requirements of the tissues in which it is found. The MCTs, which include MCT1 (SLC16A1; MIM 600682) and MCT2 (SLC16A7; MIM 603654), are characterized by 12 predicted transmembrane domains (Price et al., 1998 [PubMed 9425115]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for SLC16A3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC16A3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC16A3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:81,936,855–81,937,682 | 291.7 kb | Distal (>10kb) Multiome | 854 | |
| chr17:81,959,299–81,962,169 | 269.3 kb | Distal (>10kb) Multiome | 805 | |
| chr17:81,966,804–81,968,359 | 261.0 kb | Distal (>10kb) Multiome | 908 | |
| chr17:81,976,595–81,978,312 | 251.4 kb | Distal (>10kb) Multiome | 1001 | |
| chr17:82,019,856–82,020,391 | 208.9 kb | Distal (>10kb) Multiome | 436 | |
| chr17:82,022,355–82,024,111 | 206.0 kb | Distal (>10kb) Multiome | 898 | |
| chr17:82,029,976–82,032,662 | 197.1 kb | Distal (>10kb) Multiome | 695 | |
| chr17:82,036,902–82,037,961 | 191.4 kb | Distal (>10kb) Multiome | 892 | |
| chr17:82,051,387–82,052,184 | 177.3 kb | Distal (>10kb) Multiome | 479 | |
| chr17:82,065,558–82,066,150 | 163.2 kb | Distal (>10kb) Multiome | 967 | |
| chr17:82,096,478–82,100,203 | 130.5 kb | Distal (>10kb) Multiome | 1085 | |
| chr17:82,103,334–82,104,356 | 125.5 kb | Distal (>10kb) Multiome | 672 | |
| chr17:82,212,405–82,213,592 | 16.2 kb | Distal (>10kb) Multiome | 911 | |
| chr17:82,228,266–82,232,536 | 64 bp | At TSS Multiome | 1048 | |
| chr17:82,272,608–82,274,062 | 44.6 kb | Distal (>10kb) Multiome | 943 | |
| chr17:82,278,488–82,279,226 | 49.9 kb | Distal (>10kb) Multiome | 229 | |
| chr17:82,292,400–82,293,256 | 63.9 kb | Distal (>10kb) Multiome | 944 | |
| chr17:82,414,581–82,415,044 | 185.8 kb | Distal (>10kb) Multiome | 799 | |
| chr17:82,417,993–82,419,018 | 189.5 kb | Distal (>10kb) Multiome | 844 | |
| chr17:82,450,369–82,451,002 | 221.8 kb | Distal (>10kb) Multiome | 837 | |
| chr17:82,458,067–82,459,318 | 229.5 kb | Distal (>10kb) Multiome | 1054 | |
| chr17:82,494,122–82,495,128 | 265.7 kb | Distal (>10kb) Multiome | 1010 | |
| chr17:82,496,968–82,497,781 | 268.3 kb | Distal (>10kb) Multiome | 613 | |
| chr17:82,519,154–82,520,226 | 290.5 kb | Distal (>10kb) Multiome | 869 |
Genomic view of the SLC16A3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.