Predicted to enable DNA-binding transcription factor activity. Predicted to be involved in regulation of transcription by RNA polymerase II. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SKIDA1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SKIDA1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SKIDA1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:20,889,850–20,891,668 | 627.6 kb | Distal (>10kb) Multiome HiCAR | 385 | |
| chr10:21,281,583–21,282,796 | 235.7 kb | Distal (>10kb) Multiome HiCAR | 230 | |
| chr10:21,313,840–21,314,525 | 203.6 kb | Distal (>10kb) Multiome | 145 | |
| chr10:21,417,277–21,417,788 | 100.5 kb | Distal (>10kb) Multiome | 150 | |
| chr10:21,495,254–21,497,513 | 21.9 kb | Distal (>10kb) Multiome | 1097 | |
| chr10:21,508,081–21,511,137 | 7.3 kb | Proximal (<10kb) Multiome | 373 | |
| chr10:21,511,316–21,511,568 | 6.3 kb | Proximal (<10kb) | 43 | |
| chr10:21,515,560–21,517,745 | 1.8 kb | Proximal (<10kb) Multiome | 690 | |
| chr10:21,518,097–21,518,552 | 178 bp | At TSS | 246 | |
| chr10:21,520,150–21,520,286 | 2.2 kb | Proximal (<10kb) | 129 | |
| chr10:21,523,007–21,524,077 | 5.1 kb | Proximal (<10kb) | 224 | |
| chr10:21,524,213–21,526,810 | 8.1 kb | Proximal (<10kb) Multiome | 1100 | |
| chr10:21,527,043–21,527,629 | 9.5 kb | Proximal (<10kb) Multiome | 673 | |
| chr10:21,533,309–21,535,662 | 16.2 kb | Distal (>10kb) Multiome | 1089 | |
| chr10:21,607,324–21,607,893 | 89.7 kb | Distal (>10kb) Multiome | 105 | |
| chr10:21,727,364–21,728,215 | 209.9 kb | Distal (>10kb) Multiome | 323 | |
| chr10:21,751,037–21,752,796 | 233.7 kb | Distal (>10kb) Multiome | 246 |
Genomic view of the SKIDA1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.